| Opponent | Record (W-L-T) | Pct. | Last Played |
| Adrian College | 2-0 | 1.000 | 1976: W, 31-7 |
| Alderson Broaddus | 2-0 | 1.000 | 2018: W, 45-7 |
| Alma College | 0-1 | .000 | 1975: L, 27-6 |
| Ashland | 11-12 | .478 | 2019: L, 24-21 |
| Bowie State | 1-1 | .500 | 2022: W, 40-12 |
| Bloomsburg (Pa.) | 0-1 | .000 | 2000: L, 46-32 |
| Butler (Ind.) | 0-2 | .000 | 1992: L, 37-0 |
| California (Pa.) | 1-1 | .500 | 2010: L, 42-41 |
| Carson-Newman (Tenn.) | 0-3 | .000 | 1999: L, 41-7 |
| Central Arkansas | 0-2 | .000 | 1983: L, 27-9 |
| Central State (Ohio) | 1-3 | .250 | 1987: L, 27-17 |
| Central Oklahoma | 1-0 | 1.000 | 1983: W, 14-13 |
| DAVENPORT | 4-3 | .571 | 2024: W, 24-14 |
| Eastern Illinois | 0-1 | .000 | 1985: L, 35-27 |
| Edinboro State (Pa.) | 2-2 | .500 | 2003: W, 33-9 |
| Evansville (Ind.) | 2-0 | 1.000 | 1980: W, 13-10 |
| Fairmont St. (W.V.) | 2-0 | 1.000 | 1998: W, 23-7 |
| FERRIS STATE | 19-29-1 | .398 | 2024: L, 27-24 |
| Findlay | 9-4 | .692 | 2016: L, 37-19 |
| Franklin College (Ind.) | 3-3 | .500 | 1987: W, 24-0 |
| Gannon | 2-1 | .667 | 2025: W, 49-28 |
| GRAND VALLEY STATE | 11-42 | .208 | 2024: L, 16-9 |
| Hillsdale | 18-19 | .486 | 2015: L, 26-0 |
| Indiana (Pa.) | 1-1 | .500 | 2002: L, 27-23 |
| Indianapolis | 21-7 | .750 | 2024: W, 28-24 |
| Liberty Baptist (Va.) | 1-1 | .500 | 1983: W, 18-15 |
| Lindenwood | 0-1 | .000 | 2019: L, 35-31 |
| Lake Erie | 6-1 | .857 | 2016: W, 44-13 |
| Malone | 2-0 | 1.000 | 2013: W, 59-20 |
| Mercyhurst (Pa.) | 6-2 | .750 | 2005: F, 44-14 |
| Mexico Education | 1-0 | 1.000 | 1979: W, 77-0 |
| MICHIGAN TECH | 23-13 | .639 | 2024: L, 32-28 |
| Minnesota-Duluth | 0-1 | .000 | 2011: L, 30-27 OT |
| Nebraska-Kearney | 0-1 | .000 | 2009: L, 35-20 |
| Nebraska-Omaha | 1-0 | 1.000 | 2005: W, 24-21 |
| New Haven | 0-1 | .000 | 2025: L, 35-28 |
| Northeastern Illinois | 6-0 | 1.000 | 1980: W, 28-7 |
| Northeastern State | 0-1 | .000 | 2025: L, 28-21 |
| NORTHERN MICHIGAN | 24-20 | .545 | 2024: W, 63-14 |
| Northwood | 32-17-1 | .650 | 2024: L, 10-7 |
| Northwest Missouri State | 0-1 | .000 | 2013: L, 45-24 |
| Ohio Dominican | 0-2 | .000 | 2015: L, 24-17 |
| Presbyterian | 0-1 | .000 | 1979: L, 36-6 |
| Roosevelt | 1-0 | 1.000 | 2024: W, 27-14 |
| Salem (W.V.) | 1-0 | 1.000 | 1984: W, 30-7 |
| St. Francis (Ill.) | 5-1 | .833 | 1998: W, 59-0 |
| St. Xavier (Ill.) | 1-0 | 1.000 | 2023: W, 32-10 |
| St. Joseph's (Ind.) | 7-3 | .700 | 1995: W, 49-26 |
| St. Norbert (Wisc.) | 2-2 | .500 | 1978: W, 17-6 |
| Texas A&I | 0-1 | .000 | 1980: L, 52-0 |
| Texas A&M-Commerce | 1-0 | 1.000 | 2021: W, 20-17 (OT) |
| Texas A&M-Kingsville | 2-0 | 1.000 | 2021: W, 13-9 |
| Tiffin | 4-2 | .667 | 2019: W, 35-20 |
| Truman | 2-1 | .667 | 2024: W, 37-14 |
| Valdosta State | 1-0 | 1.000 | 2012: W, 28-24 |
| Valparaiso | 3-0 | 1.000 | 1992: W, 34-3 |
| WAYNE STATE | 33-11-1 | .744 | 2024: W, 37-10 |
| Walsh | 3-0 | 1.000 | 2018: W, 41-10 |
| Western Illinois | 0-2 | .000 | 1979: L, 27-7 |
| West Virginia Wesleyan | 1-0 | 1.000 | 2022: W, 72-0 |
| Westminster (Pa.) | 2-0 | 1.000 | 1999: W, 36-30 |
| William Penn (Iowa) | 2-0 | 1.000 | 1977: W, 31-7 |
| Winona State | 2-0 | 1.000 | 2024: W, 38-14 |
| Wisconsin-La Crosse | 0-1 | .000 | 1987: L, 20-17 |
| Youngstown State | 0-3 | .000 | 1978: L, 49-12 |
| Updated as of 9/24/2022 | |||